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Avoid too much sun. Young DS. Implementation of SI units for clinical laboratory data: Style specifications and conversion tables. Ann Intern Med 1987; 106: 114-29. Archambeaud-Mouveroux F, Nouaille Y, Nadalon S, et al. Interaction between gliclazide and cimetidine. Eur J Clin Pharmacol 1987; 315: 631. Jaakkola T, Backman JT, Neuvonen M, Laitila J, Neuvonen PJ. Effect of rifampicin on the pharmacokinetics of pioglitazone. Along with their needed effects, sulfonylureas may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

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Williams G. Management of non-insulin-dependent diabetes mellitus. Lancet 1994 Jan; 343: 95-100. Glucose administration is the basis for treatment of hypoglycemia; however, an exposure to sudden or excessive hyperglycemia caused by an injection of hypertonic glucose solution may further stimulate the sulfonylurea-primed pancreas to release more insulin, worsening the hypoglycemia. Groop LC, DeFronzo RA, Luzi L, Melander A. Hyperglycaemia and absorption of sulphonylurea drugs. Lancet 1989 Jul; 1989; 129-30. Studies in humans have not been done. Gliclazide is not recommended for use during pregnancy.

Engl J Med 1989 Nov 2; 32118: 1231-45

This is the best way to tell whether your diabetes is being controlled properly. Blood sugar testing helps you and your health care team adjust the dose of your medicine, meal plan, or exercise schedule. Distributed into the milk of rats in significant concentrations. Offspring of rats exposed to high concentrations during pregnancy developed skeletal abnormalities after nursing. Not recommended for use by nursing mothers. Do not use chocolate because its fat slows down the sugar entering the bloodstream. United Kingdom Prospective Diabetes Study Group. United Kingdom prospective diabetes study UKPDS 13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ 1995 Jan 14; 310: 83-8.

General information about glipizide

If a snack is not scheduled for an hour or more you should also eat a light snack, such as crackers or a half sandwich, or drink an 8-ounce glass of milk. Acetohexamide Dimelor, Lilly. In: Gillis MC, editor. CPS Compendium of pharmaceuticals and specialties. 33rd ed. Ottawa: Canadian Pharmacists Association; 1998. p. 498-9. Tolbutamide general monograph, CPhA. In: Krogh CME, editor. CPS Compendium of pharmaceuticals and specialties. 29th ed. Ottawa: Canadian Pharmaceutical Association; 1994. p. 1329-30.



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High blood sugar hyperglycemia is another problem related to uncontrolled diabetes. Glyburide nonmicronized has a BX rating and is not substitutable. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Know what to do if symptoms of low blood sugar occur. Eating some form of quick-acting sugar when symptoms of low blood sugar first appear will usually prevent them from getting worse. Bouchard P, Sai P, Reach G, et al. Diabetes mellitus following pentamidine-induced hypoglycemia in humans. Diabetes 1982 Jan; 311: 40-5. Food delays absorption of gliclazide up to 187 minutes; may be best taken 30 minutes before or with a meal. The doctors have prescribed 5mg Glipizide Glucotrol in addition to my regular dose of 750mg of Metformin twice daily. I have been taking this cocktail for about 4 days now, and my blood glucose levels have dropped to below 150. I've also eliminated all external sugars from my diet - no fruit juices, no sweet dairy products etc - and am exercising for 30 minutes each day. I am restricting my diet to less than 250 carbs per day. Check the labels on all your medicines such as -and-cold products because they may contain ingredients that could affect your sugar. Ask your pharmacist about using those products safely. Luntz GRWN, Smith SG. Effect of isoniazid on carbohydrate metabolism in controls and diabetics. BMJ 1953; 1: 296-99. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions.



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Dukes MNG, editor. Meyler's side effects of drugs. An encyclopedia of adverse reactions and interactons. 11th ed. Amsterdam: Elsevier; 1988. p. 893-9. Davidson MB. Rational use of sulfonylureas. Postgrad Med 1992 Aug; 922: 69-81. Has mild diuretic effect. If you experience pale skin, blurred vision, loss of consciousness, increased thirst, increased urination, fatigue, or fast, deep breathing, check your blood sugar, stop using your antibiotic and contact your doctor right away. Br J Clin Pharmacol 1986; 22: 43-8. Beta-adrenergic blocking agents, including ophthalmics, if significant absorption occurs beta-adrenergic blocking agents may decrease the hypoglycemic effects of sulfonylureas to some extent by inhibition of insulin secretion, modification of carbohydrate metabolism, and increased peripheral insulin resistance, leading to hyperglycemia; an adjustment in dose may be required. Being hospitalized if ketoacidosis or diabetic coma occurs with a possible change of treatment. Anticoagulants, coumarin- or indandione-derivative the mechanism is not completely known; however, mutual interactions of both agents have increased their anticoagulant and hypoglycemic effects. A hypoglycemic effect may be partially due to the decrease in hepatic metabolism of sulfonylureas caused by anticoagulants, which can prolong the half-life of the sulfonylureas twofold to threefold. An increased protein binding displacement of anticoagulants by sulfonylureas has been found to prolong prothrombin times; however, because of the increase in the metabolism of dicumarol that can shorten its half-life by as much as 50%, an increase, decrease, or no effect on coagulation may result. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Phillips RE, Looaressuwan S, White NJ, et al. Hypoglycaemia and antimalarial drugs: quinidine and release of insulin. BMJ 1986; 292: 1319-21. The results are questionable because negative results were also shown in rats and Chinese hamsters. Leek K, Mize R, Lowenstein SR. Glyburide-induced hypoglycaemia and ranitidine. Ann Intern Med 1987; 107: 261-2. Chlorpropamide Apo-Chlorpropamide, Apotex. In: Krogh CME, editor. CPS Compendium of pharmaceuticals and specialties. 29th ed. Ottawa: Canadian Pharmaceutical Association; 1994. finasteride



Diabetes Care 1986; 93: 320-2

Kadowaki T, Hagura R, Kajinuma H, et al. Chlorpropamide-induced hyponatremia incidence and risk factors. Diabetes Care 1983; 6: 468. Upjohn share the same NDA. As long as glyburide holds a BX rating, substitution of products of different NDAs is not permissible without the physician's permission. Occasionally, divided doses are administered, usually twice a day before the morning and evening meals, to improve gastrointestinal tolerance. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Genetic syndromes, including inborn errors of metabolism, such as glycogen-storage disease type I, or insulin-resistant syndromes, such as muscular dystrophies, late onset proximal myopathy, or Huntington's chorea. Oral, 8 mg once a day with breakfast or the first main meal. Do not take other medicines without advice from your doctor.



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Fagbemi SO, Chi L, Lucchesi BR. Antifibrillatory and profibrillatory actions of selected class I antiarrhythmic agents. J Cardiovasc Pharmacol 1993; 215: 709-19. Engl J Med 1984; 31012: 746-50. Lebovitz HE. Glipizide: a second-generation sulfonylurea hypoglycemic agent. Pharmacotherapy 1985; 5: 63-7. Dalpe-Scott, M, Heick HMC, Begin-Heick N. Oxytetracycline treatment improves the response to insulin in the spontaneously diabetic BB rat. Diabetes 1982 Jan; 31: 53-9. Brown KS, Armstrong IC, Wang A, Walker JR, Noveck RJ, Swearingen D, Allison M, Kissling JC, Kisicki J, Salazar DE. Effect of the bile acid sequestrant colesevelam on the pharmacokinetics of pioglitazone, repaglinide, estrogen estradiol, norethindrone, levothyroxine, and glyburide. Beta-adrenergic blocking agents may increase the chance that high or low blood sugar can occur. Also, they can hide symptoms of low blood sugar such as fast heartbeat. Micronized glyburide cannot be substituted for nonmicronized glyburide. Bioavailability studies have demonstrated that micronized glyburide is not bioequivalent to glyburide nonmicronized; retitration is necessary if patients are transferred. cheap altace malarone



Wilkins; 1990 p 208-9

It is unknown if this medication passes into milk. However, similar drugs pass into milk. Consult your doctor before breast-feeding. No evidence of teratogenicity was found in rats following oral administration of glimepiride at doses approximately 4000 times the maximum recommended human dose based on body surface area, or in rabbits following administration of glimepiride at doses approximately 60 times the maximum recommended human dose based on body surface area. First generation: Acetohexamide, chlorpropamide, tolazamide, tolbutamide. Chlorpropamide and tolbutamide pass into human breast milk and glimepiride passes into the milk of rats. Chlorpropamide is not recommended in nursing mothers but, in some cases, tolbutamide has been used. Nursing mothers should not take glimepiride. It is not known if other sulfonylureas pass into breast milk. Check with your doctor if you are thinking about breast-feeding. Micronized glyburide has an AB rating but may not be deemed bioequivalent according to some state formularies when the scored tablet is divided. This information is generalized and not intended as specific medical advice. Koda-Kimble MA, Young LY, editors. Applied therapeutics: the clinical use of drugs. 5th ed. Vancouver, WA: Applied Therapeutics, Inc; 1992. JANUVIA is 50 mg once daily.



Glipizide consumer information

Initial: Oral, 250 mg once a day, the dosage being increased by 250 or 500 mg every five to seven days as needed. At some point, a sulfonylurea may stop working as well and your blood sugar level will go up. You will need to know if this happens and what to do. Instead of taking more of this medicine, your doctor may change you to another sulfonylurea. Or your doctor may have you inject small doses of insulin or take another oral antidiabetic medicine called metformin along with your sulfonylurea to help the insulin you make work better. If that does not bring down the amount of sugar in your blood, your doctor may have you stop taking the oral antidiabetic agents and begin receiving only insulin injections. Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT. Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide. Stapleton JT, Gillman MW. Hypoglycemic coma due to disopyramide toxicity. South Med J 1983; 76: 1453. Gram J, Kold A, Jespersen J. Rise of plasma t-PA fibrinolytic activity in a group of maturity onset diabetic patients shifted from a first generation tolbutamide to a second generation sulphonylurea gliclazide. J Intern Med 1989; 2254: 241-7. Reduces serum uric acid concentration. Zaman R, Kendall MJ, Biggs PI. The effect of acebutalol and propranolol on the hypoglycaemic action of glibenclamide. Br J Clin Pharmacol 1982; 13: 507-12. how to purchase sibutramine stock



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Check with your doctor or pharmacist to find out what you should do if you miss a meal. This dose should also be used in patients with medical problems that make them more sensitive to the effects of glyburide. Kristensen M, Hansen JM. Potentiation of the tolbutamide effect by dicoumarol. Diabetes 1967; 16: 211-4. TEQUIN gatifloxacin and serious hypoglycemia and hyperglycemia. Bristol-Myers Squibb Canada May 12, 2006. During conversion from insulin therapy to glyburide therapy, no gradual dosage adjustment usually is required for patients using less than 40 USP Units of insulin daily. Patients requiring more than 40 USP Units should receive a 50% reduction of insulin the first day with initiation of 3 mg of micronized glyburide or 5 mg of nonmicronized glyburide as a single dose and gradual dosage adjustments of glyburide as needed. Hospitalization for some patients on a higher insulin dosage may be required for uneventful conversion. Studies in male mice and male and female rats given more than 1700 times and approximately 4000 times, respectively, the maximum recommended human dose based on body surface area showed no evidence of impaired fertility.



Important information

Then, your doctor may change your dose a little at a time if needed. The dose is usually not more than 40 mg a day. If your dose is 15 mg or more, the dose is usually divided into two doses. These doses are taken thirty minutes before the morning and evening meals. Discuss the risks and benefits with your doctor. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Ferriere M, Lachkar H, Richard JL, et al. Captopril and insulin sensitivity. Ann Intern Med 1985; 102: 134-5. May be preferred for those patients with moderate renal function impairment; should not be used with severe renal failure. MacWalter RS, Debani AH, Feeley J, et al. Potentiation by ranitidine of the hypoglycaemic response to glipizide in diabetic patients. Br J Clin Pharmacol 1985; 21: 121-2. Specific carcinogenicity studies have not been done in animals; however, long-term toxicity studies have not shown any evidence of drug-related carcinogenicity. Rocha AS, Ping WC, Kudo LH. Effect of chlorpropamide on water and urea transport in the inner medullary collecting duct. Kidney Int 1991 Jan; 391: 79-86. Vigneri R, Trischitta V, Italia S, et al. Treatment of NIDDM patients with secondary failure to glyburide: comparison of the addition of either metformin or bedtime NPH insulin to glyburide. Diabete Metab 1991 May; 17 1 Pt 20: 232-4. Mouradian M, Abourizk N. Diabetes mellitus and thyroid disease. Diabetes Care 1983 Sep-Oct; 65: 512-20. Morley JE, Perry HM. The management of diabetes mellitus in older individuals. Drugs 1991; 414: 548-65. Judis J. Binding of sulfonylureas to serum proteins. J Pharm Sci 1972; 611: 89-93. The United States pharmacopeia. The national formulary. USP 23rd revision January 1, 1995. NF 18th ed January 1, 1995. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1995 Sixth supplement, 1997. p. 3679. The presence of other medical problems may affect the use of the sulfonylurea antidiabetic medicines. Micronized glyburide has an AB rating. However, some state formularies may not consider certain generic products bioequivalent when scored tablets are divided; state formularies should be checked before substituting one product for another. Your doctor will give you instructions about diet, exercise, how to test your blood sugar levels, and how to adjust your dose when you are sick. abilify



What other drugs will affect glipizide

Crockett SE, Marsh D, Lewis RP, et al. Lack of cardiac inotropic effect of tolbutamide in intact man. Metabolism 1974; 823: 763-9. F in a well-closed container, unless otherwise specified by manufacturer. Some elderly patients may be more sensitive than younger adults to the effects of sulfonylureas, especially when more than one antidiabetic medicine is being taken or if other medicines that affect blood sugar are also being taken. This may increase your chance of developing low blood sugar during treatment. Furthermore, the first signs of low or high blood sugar are not easily seen or do not occur at all in older patients. This may increase the chance of low blood sugar developing during treatment. When adjusting the dose in the elderly, consider that steady-state concentrations for glipizide extended-release tablets may be delayed by approximately one or two days as compared to other age groups. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Studies in humans have not been done. Use should be discontinued at least 2 weeks before the expected delivery date. Glyburide general monograph, CPhA. In: Krogh CME, editor. CPS Compendium of pharmaceuticals and specialties. 29th ed. Ottawa: Canadian Pharmaceutical Association; 1994. p. 525-6. SIADH electrolyte imbalance hyponatremia. Moderate. These medicines may cause some risk when taken together. Neuvonen PJ, Karkainen S. Effects of charcoal, sodium bicarbonate, and ammonium chloride on chlorpropamide kinetics. Clin Pharmacol Ther 1983; 33: 386-93.



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Initial: Oral, 100 to 250 mg once a day with breakfast or the first main meal, with dosage being changed by 100 to 250 mg at weekly intervals as needed. Diabetes Res Clin Prac 1985; Suppl 1: S522. The Ames test, human lymphocyte test, and micronucleus test did not reveal mutagenicity. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Basler A, Baumann M, Rohrborn G. In vitro testing of chlorpropamide with human lymphocyte cultures in the presence of liver microsome fraction S9 mix of rats. Arzneimittelforschung 1982; 327: 724-6. At first, 5 milligrams mg once a day. If you are taking colesevelam, take glipizide at least 4 hours before taking colesevelam. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. metformin full cost



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Keep all regular medical and laboratory appointments. Upjohn. In: PDR Physicians' desk reference. 52nd ed. 1998. Montvale, NJ: Medical Economics Company; 1998. p. 2280-2. USP DI Volume III, Approved drug products and legal requirements. 18th ed. Rockville, MD: The United States Pharmacopeial Convention, Inc; 1998. Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines, such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems. Tolbutamide Apo-Tolbutamide, Apotex. In: Gillis MC, editor. CPS Compendium of pharmaceuticals and specialties. 33rd ed. Ottawa: Canadian Pharmacists Association; 1998. p. 122. Seltzer HS. Drug-induced hypoglycemia: a review based on 1418 cases. Endocrinol Metab Clin North Am 1989 Mar; 181: 163-81. With chronic sulfonylurea treatment, insulin production is not increased and may return to pretreatment values, but insulin efficacy continues and is thought to involve extrapancreatic mechanisms to increase insulin sensitivity in target tissues, such as liver, muscle, and fat as well as in other cells, such as monocytes and erythrocytes. This can result in a decrease in hepatic glycogenolysis and gluconeogenesis. It is unclear if the sulfonylurea's extrapancreatic actions that increase insulin's efficacy are direct or indirect effects, but it is clear that the mechanism of action is not due to a direct sulfonylurea action on the insulin receptor. Because this peripheral effect is not apparent in patients with type 1 diabetes, the evidence suggests that this may not be the clinically significant mechanism of sulfonylurea action in patients with type 2 diabetes either. However, it is clear that tissues of sulfonylurea-treated patients with type 2 diabetes become more responsive to lower concentrations of endogenous insulin. Primary failure of sulfonylurea therapy may occur if beta-cell function is severely impaired. Glimepiride alone: At first, 1 to 2 milligrams mg once a day with breakfast or the first main meal. The dose then may be increased by your doctor based on your blood sugar level. Chlorpropamide seems to potentiate the effect of minimal concentrations of antidiuretic hormone present in patients with partial central diabetes insipidus. Leslie RDG, Pyke DA. Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes. BMJ 1978; 2: 1519. Jackson RA. Mechanisms of age-related glucose intolerance. Diabetes Care 1990 Feb; 13 Suppl 2: 9-19. Jacobs DS, DeMott WR, Strobel SL, et al. Chemistry. In: Jacobs DS, Kasten BL, DeMott WR, editors. Laboratory test handbook.



Glipizide dosing information

The number of tablets that you take depends on the strength of the medicine. McCaleb ML, Maloff BL, Nowak SM, et al. Sulfonylurea effects on target tissues for insulin. Diabetes Care 1984; 7 Suppl 1: 42-6. Ped Res 1981; 15: 626. At first, 1000 to 2000 milligrams mg a day. Some elderly people may need lower doses to start. The dose is usually divided into two doses. These doses are taken before the morning and evening meals. Your doctor may change your dose a little at a time if needed. The dose is usually not more than 3000 mg a day. It occurs more often with long-acting sulfonylureas, such as chlorpropamide or glyburide, when other predisposing factors or conditions are present, and can be relapsing and prolonged; glyburide results in a higher fatality rate than does chlorpropamide. Hartling SG, Faber OK, Wegmann ML, et al. Interaction of ethanol and glipizide in humans. Diabetes Care 1987; 106: 683-6. If an elderly patient tends toward hypoglycemia during the first twenty-four hours after an initial dose of 250 mg at breakfast, the dose should be reduced or the medication discontinued. Sulfonylureas can make you more sensitive to the sun. Use of sunblock products that have a skin protection factor SPF of at least 15 on your skin and lips can help to prevent sunburn. Do not use a sunlamp or tanning bed or booth. Documenting blood glucose and rechecking in 15 minutes. Lithium these medications have intrinsic hyperglycemic activity in both diabetic and nondiabetic patients; dosage of the sulfonylurea may need to be modified during and after treatment. ufac.info hydrea



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Side Effects List Glipizide-Metformin side effects by likelihood and severity. Zheng HX, Huang Y, Frassetto LA, Benet LZ. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. The use of sulfonylurea antidiabetic agents has been reported, but not proven in all studies, to increase the risk of death from heart and blood vessel disease. Patients with diabetes are already more likely to have these problems if they do not control their blood sugar. Some sulfonylureas, such as glyburide and gliclazide, can have a positive effect on heart and blood vessel disease. It is important to know that problems can occur, but it is also not known if other sulfonylureas, particularly tolbutamide, help to cause these problems. It is known that if blood sugar is not controlled, such problems can occur.

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Danazol Sanofi Winthrop. In: PDR Physicians' desk reference. 48th ed. 1994. Montvale, NJ: Medical Economics Data Production Company; 1994. p. 2092-3. No teratogenic effects were found in studies in rats and rabbits. Glyburide Gen-Glybe, Genpharm. In: Gillis MC, editor. CPS Compendium of pharmaceuticals and specialties. 33rd ed. Ottawa: Canadian Pharmacists Association; 1998. p. 668. Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

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An extra dose or an injection of insulin may be needed if your blood sugar does not come down shortly. Studies in male and female rats given 75 times the maximum human dose showed no evidence of impaired fertility. Miners JO, Foenander T, Wanwimolruk S, Gallus AS, et al. The effect of sulphinpyrazone on oxidative drug metabolism in man: inhibition of tolbutamide elimination. Eur J Clin Pharmacol 1982: 224: 321-6. Breimer DD, Zilly W, Richter E. Influence of corticosteroids on hexobarbital and tolbutamide disposition. Clin Pharmacol Ther 1978; 242: 208-12.

Studies in humans have not been done

Safety and efficacy have not been established. Facchini F, Chen YDI, Reaven GM. Light-to-moderate alcohol intake is associated with enhanced insulin sensitivity. Diabetes Care 1994 Feb; 172: 115-9. Chlorpropamide crosses the placenta; glyburide does not significantly cross the placenta, and it is not known whether other sulfonylureas cross the placenta. Use of insulin rather than sulfonylurea antidiabetic agents during pregnancy allows for the maintenance of blood glucose concentrations that are as close to normal as possible. Abnormal blood glucose concentrations in the mother have been associated with a higher incidence of congenital abnormalities during early pregnancy, and with increased perinatal morbidity and mortality later in pregnancy. Adequate and well-controlled studies in humans have not been done to determine whether sulfonylureas are teratogenic. It remains possible that sulfonylureas cause congenital malformations if they cross the placenta, but current data leave unresolved the issue of whether the abnormalities are due to poor glucose control or to sulfonylurea treatment. Generally, sulfonylureas are not recommended during pregnancy. In the rare case that sulfonylureas are used during pregnancy, they should be discontinued to allow an interval before delivery appropriate for the particular sulfonylurea being used because of the risk that they will cause insulin release and hypoglycemia in the neonate at delivery.

Batch J, Ma A, Bird D, et al. The effects of ingestion time of gliclazide in relationship to meals on plasma glucose, insulin and C-peptide levels. Eur J Clin Pharmacol 1990; 385: 465-7. Gastric removal by administration of repeated doses of oral activated charcoal with appropriate cathartic, although the usefulness of this has not been established. If any of these effects persist or worsen, tell your doctor or promptly. Weight gain is greater with combination use of insulin and sulfonylureas than with sulfonylurea therapy alone. Gliclazide alone, or metformin in combination with sulfonylureas, usually results in less weight gain than other sulfonylureas and has exhibited a weight loss effect.

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